HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors

HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors

Abstract Identifying receptors for bat coronaviruses is critical for spillover risk assessment, countermeasure development, and pandemic preparedness. While Middle East respiratory syndrome coronavirus (MERS-CoV) uses DPP4 for entry, the receptors of many MERS-related betacoronaviruses remain unknow...

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Main Authors: Mia Madel Alfajaro, Emma L. Keeler, Ning Li, Nicholas J. Catanzaro, I-Ting Teng, Zhe Zhao, Michael W. Grunst, Boyd Yount, Alexandra Schäfer, Danyi Wang, Arthur S. Kim, Aleksandra Synowiec, Mario A. Peña-Hernández, Samantha Zepeda, Ridwan Arinola, Ramandeep Kaur, Bridget L. Menasche, Jin Wei, Gabriel A. Russell, John Huck, Jaewon Song, Aaron Ring, Akiko Iwasaki, Rohit K. Jangra, Sanghyun Lee, David R. Martinez, Walther Mothes, Pradeep D. Uchil, John G. Doench, Alicen B. Spaulding, Ralph S. Baric, Leonid Serebryannyy, Yaroslav Tsybovsky, Tongqing Zhou, Daniel C. Douek, Craig B. Wilen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61583-7
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https://doi.org/10.1038/s41467-025-61583-7

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