Evaluation of the Risk of Clinical Deterioration among Inpatients with COVID-19
This study aims to assess the risk of severe forms of COVID-19, based on clinical, laboratory, and imaging markers in patients initially admitted to the ward. This is a retrospective observational study, with data from electronic medical records of inpatients, with laboratory confirmation of COVID-1...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2021/6689669 |
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| author | Víctor O. Costa Eveline M. Nicolini Bruna M. A. da Costa Fabrício M. Teixeira Júlia P. Ferreira Marcos A. Moura Jorge Montessi Rogério L. Campos Andrea N. Guaraldo Patrícia M. Costa |
| author_facet | Víctor O. Costa Eveline M. Nicolini Bruna M. A. da Costa Fabrício M. Teixeira Júlia P. Ferreira Marcos A. Moura Jorge Montessi Rogério L. Campos Andrea N. Guaraldo Patrícia M. Costa |
| author_sort | Víctor O. Costa |
| collection | DOAJ |
| description | This study aims to assess the risk of severe forms of COVID-19, based on clinical, laboratory, and imaging markers in patients initially admitted to the ward. This is a retrospective observational study, with data from electronic medical records of inpatients, with laboratory confirmation of COVID-19, between March and September 2020, in a hospital from Juiz de Fora-MG, Brazil. Participants (n = 74) were separated into two groups by clinical evolution: those who remained in the ward and those who progressed to the ICU. Mann–Whitney U test was taken for continuous variables and the chi-square test or Fisher’s exact test for categorical variables. Comparing the proposed groups, lower values of lymphocytes (p = <0.001) and increases in serum creatinine (p = 0.009), LDH (p = 0.057), troponin (p = 0.018), IL-6 (p = 0.053), complement C4 (p = 0.040), and CRP (p = 0.053) showed significant differences or statistical tendency for clinical deterioration. The average age of the groups was 47.9 ± 16.5 and 66.5 ± 7.3 years (p = 0.001). Hypertension (p = 0.064), heart disease (p = 0.048), and COPD (p = 0.039) were more linked to ICU admission, as well as the presence of tachypnea on admission (p = 0.051). Ground-glass involvement >25% of the lung parenchyma or pleural effusion on chest CT showed association with evolution to ICU (p = 0.027), as well as bilateral opacifications (p = 0.030) when compared to unilateral ones. Laboratory, clinical, and imaging markers may have significant relation with worse outcomes and the need for intensive treatment, being helpful as predictive factors. |
| format | Article |
| id | doaj-art-6ba767f247cf46309ce0d6e4dee30d21 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-6ba767f247cf46309ce0d6e4dee30d212025-08-20T03:33:46ZengWileyAdvances in Virology1687-86391687-86472021-01-01202110.1155/2021/66896696689669Evaluation of the Risk of Clinical Deterioration among Inpatients with COVID-19Víctor O. Costa0Eveline M. Nicolini1Bruna M. A. da Costa2Fabrício M. Teixeira3Júlia P. Ferreira4Marcos A. Moura5Jorge Montessi6Rogério L. Campos7Andrea N. Guaraldo8Patrícia M. Costa9Medicine, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora–SUPREMA, Juiz de Fora 36033-003, BrazilThoracic Surgery, Hospital Monte Sinai, Juiz de Fora 36033-318, BrazilNursing, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora–Suprema, Juiz de Fora 36033-003, BrazilMedicine, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora–SUPREMA, Juiz de Fora 36033-003, BrazilMedicine, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora–SUPREMA, Juiz de Fora 36033-003, BrazilInfectology, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora-Suprema, Juiz de Fora 36033-003, BrazilThoracic Surgery, Hospital Monte Sinai, Juiz de Fora 36033-318, BrazilPsychiatrist and Emergency, Hospital Monte Sinai, Juiz de Fora 36033-318, BrazilIntensive Therapy, Hospital Monte Sinai, Juiz de Fora 36033-318, BrazilIntensive Therapy and Dermatology Hospital Monte Sinai, Juiz de Fora 36033-318, BrazilThis study aims to assess the risk of severe forms of COVID-19, based on clinical, laboratory, and imaging markers in patients initially admitted to the ward. This is a retrospective observational study, with data from electronic medical records of inpatients, with laboratory confirmation of COVID-19, between March and September 2020, in a hospital from Juiz de Fora-MG, Brazil. Participants (n = 74) were separated into two groups by clinical evolution: those who remained in the ward and those who progressed to the ICU. Mann–Whitney U test was taken for continuous variables and the chi-square test or Fisher’s exact test for categorical variables. Comparing the proposed groups, lower values of lymphocytes (p = <0.001) and increases in serum creatinine (p = 0.009), LDH (p = 0.057), troponin (p = 0.018), IL-6 (p = 0.053), complement C4 (p = 0.040), and CRP (p = 0.053) showed significant differences or statistical tendency for clinical deterioration. The average age of the groups was 47.9 ± 16.5 and 66.5 ± 7.3 years (p = 0.001). Hypertension (p = 0.064), heart disease (p = 0.048), and COPD (p = 0.039) were more linked to ICU admission, as well as the presence of tachypnea on admission (p = 0.051). Ground-glass involvement >25% of the lung parenchyma or pleural effusion on chest CT showed association with evolution to ICU (p = 0.027), as well as bilateral opacifications (p = 0.030) when compared to unilateral ones. Laboratory, clinical, and imaging markers may have significant relation with worse outcomes and the need for intensive treatment, being helpful as predictive factors.http://dx.doi.org/10.1155/2021/6689669 |
| spellingShingle | Víctor O. Costa Eveline M. Nicolini Bruna M. A. da Costa Fabrício M. Teixeira Júlia P. Ferreira Marcos A. Moura Jorge Montessi Rogério L. Campos Andrea N. Guaraldo Patrícia M. Costa Evaluation of the Risk of Clinical Deterioration among Inpatients with COVID-19 Advances in Virology |
| title | Evaluation of the Risk of Clinical Deterioration among Inpatients with COVID-19 |
| title_full | Evaluation of the Risk of Clinical Deterioration among Inpatients with COVID-19 |
| title_fullStr | Evaluation of the Risk of Clinical Deterioration among Inpatients with COVID-19 |
| title_full_unstemmed | Evaluation of the Risk of Clinical Deterioration among Inpatients with COVID-19 |
| title_short | Evaluation of the Risk of Clinical Deterioration among Inpatients with COVID-19 |
| title_sort | evaluation of the risk of clinical deterioration among inpatients with covid 19 |
| url | http://dx.doi.org/10.1155/2021/6689669 |
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