Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis

Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis

Summary: The gut microbiota and its metabolites have been implicated in calcium oxalate (CaOx) nephrolithiasis, while the precise mechanism remains unclear. We report that the gut microbiota dysbiosis in patients with CaOx nephrolithiasis results in an elevated level of deoxycholic acid (DCA) and di...

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Main Authors: Linhu Liu, Yucheng Ma, Zhongyu Jian, Banghua Liao, Ya Li, Lede Lin, Menghua Wang, Jiawei Chen, Jingwen Wei, Mengzhu Yang, Yu Liu, Yiqiong Yuan, Jun Wen, Liyuan Xiang, Shiqian Qi, Xi Jin, Kunjie Wang
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Microbiology
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007077
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http://www.sciencedirect.com/science/article/pii/S2211124725007077

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