Beneficial Actions of 4-Methylumbelliferone in Type 1 Diabetes by Promoting β Cell Renewal and Inhibiting Dedifferentiation

Beneficial Actions of 4-Methylumbelliferone in Type 1 Diabetes by Promoting β Cell Renewal and Inhibiting Dedifferentiation

<b><b>Background/Objectives</b></b>: This study aims to investigate the effects of 4-methylumbelliferone (4-MU) on islet morphology, cell phenotype and function, and to explore possible mechanisms of β cell regeneration. <b>Methods</b>: The Type 1 diabetes (T1D) m...

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Bibliographic Details
Main Authors: Wencheng Zhang, Shuo Yang, Xinwen Yu, Shanshan Zhu, Xin Wang, Fei Sun, Shengru Liang, Xiaoguang Wang, Guohong Zhao, Bin Gao
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomedicines
Subjects:
4-methylumbelliferone
Type 1 diabetes
β cells
streptozotocin
dedifferentiation
Online Access:https://www.mdpi.com/2227-9059/12/12/2790
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