Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube

Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube

Abstract The human Fallopian tube (FT) is an important organ in the female reproductive system and has been implicated as a site of origin for pelvic serous cancers, including high-grade serous tubo-ovarian carcinoma (HGSC). We have generated comprehensive whole-genome bisulfite sequencing, RNA-seq,...

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Main Authors: Ian Beddows, Svetlana Djirackor, Dalia K. Omran, Euihye Jung, Natalie NC Shih, Ritu Roy, Aaron Hechmer, Adam Olshen, Guillaume Adelmant, Ann Tom, Jacob Morrison, Marie Adams, Daniel C. Rohrer, Lauren E. Schwartz, Celeste Leigh Pearce, Heidi Auman, Jarrod A. Marto, Charles W. Drescher, Ronny Drapkin, Hui Shen
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58145-2
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https://doi.org/10.1038/s41467-025-58145-2

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