Impaired hippocampal circuit function underlying memory encoding and consolidation precede robust Aβ deposition in a mouse model of alzheimer’s disease

Impaired hippocampal circuit function underlying memory encoding and consolidation precede robust Aβ deposition in a mouse model of alzheimer’s disease

Abstract Current therapeutic strategies for Alzheimer’s disease (AD) target amyloid-beta (Aβ) fibrils and high molecular weight protofibrils associated with plaques, but molecular cascades associated with AD may drive neural systems failure before Aβ plaque deposition in AD. Employing hippocampal el...

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Bibliographic Details
Main Authors: Hanyan Li, Zhuoyang Zhao, Aline Fassini, Han K. Lee, Reese J. Green, Stephen N. Gomperts
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
Amyloid-beta
Hippocampus
Place cell
Electrophysiology
Sleep
Online Access:https://doi.org/10.1038/s41598-025-05653-2
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https://doi.org/10.1038/s41598-025-05653-2

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