Structural basis of TMPRSS11D specificity and autocleavage activation

Structural basis of TMPRSS11D specificity and autocleavage activation

Abstract Transmembrane Protease, Serine-2 (TMPRSS2) and TMPRSS11D are human proteases that enable SARS-CoV-2 and Influenza A/B virus infections, but their biochemical mechanisms for facilitating viral cell entry remain unclear. We show these proteases spontaneously and efficiently cleave their own z...

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Main Authors: Bryan J. Fraser, Ryan P. Wilson, Sára Ferková, Olzhas Ilyassov, Jackie Lac, Aiping Dong, Yen-Yen Li, Alma Seitova, Yanjun Li, Zahra Hejazi, Tristan M. G. Kenney, Linda Z. Penn, Aled Edwards, Richard Leduc, Pierre-Luc Boudreault, Gregg B. Morin, François Bénard, Cheryl H. Arrowsmith
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59677-3
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https://doi.org/10.1038/s41467-025-59677-3

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