The Alzheimer's Prevention Initiative Generation Program: Study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer's disease

The Alzheimer's Prevention Initiative Generation Program: Study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer's disease

Abstract Introduction Alzheimer's disease (AD) pathology, including the accumulation of amyloid beta (Aβ) species and tau pathology, begins decades before the onset of cognitive impairment. This long preclinical period provides an opportunity for clinical trials designed to prevent or delay the...

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Bibliographic Details
Main Authors: Cristina Lopez Lopez, Pierre N. Tariot, Angelika Caputo, Jessica B. Langbaum, Fonda Liu, Marie‐Emmanuelle Riviere, Carolyn Langlois, Marie‐Laure Rouzade‐Dominguez, Martin Zalesak, Suzanne Hendrix, Ronald G. Thomas, Vissia Viglietta, Rob Lenz, J. Michael Ryan, Ana Graf, Eric M. Reiman
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Alzheimer's disease
Preclinical Alzheimer's disease
Mild cognitive impairment
Umibecestat
CNP520
BACE‐1 inhibitor
Online Access:https://doi.org/10.1016/j.trci.2019.02.005
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https://doi.org/10.1016/j.trci.2019.02.005

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