Beware of <i>N</i>-Benzoyloxybenzamides

Following a High-Throughput Screening campaign to discover inhibitors of acid ceramidase, we report the novel and extremely potent covalent inhibitor, <b>1</b>. Following resynthesis and stability monitoring, we discovered that <b>1</b> is chemically unstable and reacts with...

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Bibliographic Details
Main Authors: Jonathan Cubitt, Mari Davies, Ross Riseley, Gabrielle Evans, Sian E. Gardiner, Benson M. Kariuki, Simon E. Ward, Emyr Lloyd-Evans, Helen Waller-Evans, D. Heulyn Jones
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Molecules
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Online Access:https://www.mdpi.com/1420-3049/29/21/5143
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