High expression of ITGB3 ameliorates asthma by inhibiting epithelial-mesenchymal transformation through suppressing the activation of NF-kB pathway

High expression of ITGB3 ameliorates asthma by inhibiting epithelial-mesenchymal transformation through suppressing the activation of NF-kB pathway

Abstract Integrin β3 (ITGB3) has been identified as an asthma-associated gene; however, its molecular mechanisms remain poorly understood. Epithelial-mesenchymal transition (EMT) is a critical driver of airway remodeling in asthma, which underpins disease progression. This study aimed to elucidate t...

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Bibliographic Details
Main Authors: Lu Luo, Xiaoshan Yang, Haitao Zhao, Lingling Wang, Wengang Li, Yan Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Asthma
Integrin beta3
NF-κB
Epithelial-mesenchymal transformation
Online Access:https://doi.org/10.1038/s41598-025-98842-y
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https://doi.org/10.1038/s41598-025-98842-y

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