TRPC3 contributes to cyclophosphamide-induced cystitis progression by enhancing bladder fibrosis through activation of the TGF-β/smad pathway

TRPC3 contributes to cyclophosphamide-induced cystitis progression by enhancing bladder fibrosis through activation of the TGF-β/smad pathway

BackgroundBladder pain syndrome/Interstitial cystitis (BPS/IC) is a chronic urological disorder affecting 2.7%–6.5% of the population. The condition is characterized by significant bladder-related pain, with approximately 50% of IC/BPS patients exhibiting bladder fibrosis. Transient receptor potenti...

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Bibliographic Details
Main Authors: Ruixiang Luo, Wenshuang Li, Junlong Huang, Zheng Liu, Chi Zhang, Honglu Ding, Jialiang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
interstitial cystitis
bladder pain syndrome
bladder fibrosis
TRPC3
TGF-β
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1565156/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1565156/full

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