The Non‐Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF‐β‐E2F1 Axis

The Non‐Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF‐β‐E2F1 Axis

Abstract Sustained activation of hepatic stellate cells (HSCs) drives liver fibrosis in response to chronic liver injury and inflammation. It is reported that profibrogenic signals released from stressed/injured hepatocytes evoke fibrogenic responses in HSCs. However, intrahepatocyte players that mo...

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Bibliographic Details
Main Authors: Jian Zhang, Yuee Zhao, Gauthami Pulivendala, Qing Zhang, Liangyou Rui, Jiashi Gao, Huiwen Wang, Gary Zhang, Alli Nuotio‐Antar, Xin Tong, Lei Yin
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
ChREBPα
E2F1
hepatic stellate cells
liver fibrosis
TGF‐β signaling
Online Access:https://doi.org/10.1002/advs.202415032
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https://doi.org/10.1002/advs.202415032

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