Puerarin prevents cadmium-induced endoplasmic reticulum stress via SIRT1-dependent PERK-CHOP pathway in HepG2 cells

Puerarin prevents cadmium-induced endoplasmic reticulum stress via SIRT1-dependent PERK-CHOP pathway in HepG2 cells

Cadmium (Cd) is a high-risk heavy metal that induces oxidative stress, endoplasmic reticulum (ER) stress and inflammation, damaging organs such as the liver. Puerarin (PUE) has been shown to treat liver injury and especially prevent Cd-induced hepatic damage via its antioxidant activity. Sirtuin 1 (...

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Bibliographic Details
Main Authors: Huang Di, Qiu Mengqi, Luo Kuanhong, Zhu Yanzhe, Zhang Siyu, He Zhen, Hu Xiaobo, Cao Zhaohui
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2025-04-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
puerarin
cadmium
ER stress
SIRT1
apoptosis
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2025039
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https://www.sciengine.com/doi/10.3724/abbs.2025039

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