Analysis of nanomedicine primary tumor vs. metastasis targeting using clinical-stage core-crosslinked polymeric micelles

Analysis of nanomedicine primary tumor vs. metastasis targeting using clinical-stage core-crosslinked polymeric micelles

Summary: Targeting and treating metastatic cancer remain major clinical challenges. We developed an optically imageable metastatic mouse model based on near-infrared protein-expressing 4T1 triple-negative breast cancer cells. Using multimodal imaging, we studied the tumor and metastasis tropism of c...

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Main Authors: Larissa Yokota Rizzo, Federica De Lorenzi, Saskia von Stillfried, Seyed Mohammadali Dadfar, Qizhi Hu, Sanjay Tiwari, Claus-Christian Glüer, Marielle Thewissen, Felix Gremse, Stephan Rütten, Peter Boor, Wilhelm Jahnen-Dechent, Ruth Knüchel-Clarke, Fabian Kiessling, Cristianne J.F. Rijcken, Alexandros Marios Sofias, Twan Lammers
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008575
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