Chronic inflammation degrades CD4 T cell immunity to prior vaccines in treated HIV infection

Chronic inflammation degrades CD4 T cell immunity to prior vaccines in treated HIV infection

Abstract To date, our understanding of how HIV infection impacts vaccine-induced cellular immunity is limited. Here, we investigate inflammation, immune activation and antigen-specific T cell responses in HIV-uninfected and antiretroviral-treated HIV-infected people. Our findings highlight lower rec...

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Main Authors: Melissa Kießling, John J. Cole, Sabrina Kübel, Paulina Klein, Klaus Korn, Amy R. Henry, Farida Laboune, Slim Fourati, Ellen Harrer, Thomas Harrer, Daniel C. Douek, Klaus Überla, Krystelle Nganou-Makamdop
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54605-3
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https://doi.org/10.1038/s41467-024-54605-3

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