Nitration of the DBHA Cyclopropanecarboxylate Enolate – A New and Efficient Route to 1 -Aminocyclopropane-1 -carboxylic Acid
1-Aminocyclopropane-1-carboxylic acid (1) is synthesized from 2,6-di-tert-butyl-4-methoxy-phenyl cyclopropanecarboxylate (4) by an overall electrophilic amination. Key step is the nitration of the highly reactive enolate 5 generated by deprotonation of the ester 4 with tert-butyllithium.
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| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
1985-11-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9695 |
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