RUNX1 promotes proliferation of cervical cancer through TGFB2-MAPK pathway
Abstract As cervical cancer (CC) caused more than 300,000 deaths in the world, it is urgent to identify therapeutic targets to improve survival. Though RUNX1 is overexpressed in CC, its specific role and underlying molecular mechanisms remain incompletely understood. Here we presented that RUNX1 was...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-84254-x |
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| author | Yongqin Jia Neng Yang Shuai Tang Li Deng Yanzhou Wang Xiongwei Cai |
| author_facet | Yongqin Jia Neng Yang Shuai Tang Li Deng Yanzhou Wang Xiongwei Cai |
| author_sort | Yongqin Jia |
| collection | DOAJ |
| description | Abstract As cervical cancer (CC) caused more than 300,000 deaths in the world, it is urgent to identify therapeutic targets to improve survival. Though RUNX1 is overexpressed in CC, its specific role and underlying molecular mechanisms remain incompletely understood. Here we presented that RUNX1 was upregulated in CC and associated with poor prognosis. Functional studies demonstrated that RUNX1 acts as an oncogene in CC, with overexpression accelerating cell cycle progression and promoting cell proliferation. Mechanistically, RUNX1 regulates the MAPK pathway by modulating TGFB2 expression, while TGFB2 inhibition impaired MAPK pathway activation and the proliferation driven by RUNX1 overexpression. Comprehensive analyses also suggested that RUNX1 may modulate the immune microenvironment in CC through TGFB2. These findings indicate that RUNX1 promotes CC progression by activating the MAPK pathway through upregulation of TGFB2. Our study provides new insights into the role of RUNX1 in CC proliferation and suggests RUNX1 as a potential therapeutic target in CC. |
| format | Article |
| id | doaj-art-6b0463273a14473b91cb032fbeeae719 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-6b0463273a14473b91cb032fbeeae7192025-01-05T12:14:15ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-024-84254-xRUNX1 promotes proliferation of cervical cancer through TGFB2-MAPK pathwayYongqin Jia0Neng Yang1Shuai Tang2Li Deng3Yanzhou Wang4Xiongwei Cai5Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University (Army Medical University)Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University (Army Medical University)Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University (Army Medical University)Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University (Army Medical University)Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University (Army Medical University)Department of Gynecology, Chongqing Health Center for Women and Children (Women and Children’s Hospital of Chongqing Medical University)Abstract As cervical cancer (CC) caused more than 300,000 deaths in the world, it is urgent to identify therapeutic targets to improve survival. Though RUNX1 is overexpressed in CC, its specific role and underlying molecular mechanisms remain incompletely understood. Here we presented that RUNX1 was upregulated in CC and associated with poor prognosis. Functional studies demonstrated that RUNX1 acts as an oncogene in CC, with overexpression accelerating cell cycle progression and promoting cell proliferation. Mechanistically, RUNX1 regulates the MAPK pathway by modulating TGFB2 expression, while TGFB2 inhibition impaired MAPK pathway activation and the proliferation driven by RUNX1 overexpression. Comprehensive analyses also suggested that RUNX1 may modulate the immune microenvironment in CC through TGFB2. These findings indicate that RUNX1 promotes CC progression by activating the MAPK pathway through upregulation of TGFB2. Our study provides new insights into the role of RUNX1 in CC proliferation and suggests RUNX1 as a potential therapeutic target in CC.https://doi.org/10.1038/s41598-024-84254-xCervical cancerRUNX1ProliferationMAPK pathwayTGFB2Immune microenvironment |
| spellingShingle | Yongqin Jia Neng Yang Shuai Tang Li Deng Yanzhou Wang Xiongwei Cai RUNX1 promotes proliferation of cervical cancer through TGFB2-MAPK pathway Scientific Reports Cervical cancer RUNX1 Proliferation MAPK pathway TGFB2 Immune microenvironment |
| title | RUNX1 promotes proliferation of cervical cancer through TGFB2-MAPK pathway |
| title_full | RUNX1 promotes proliferation of cervical cancer through TGFB2-MAPK pathway |
| title_fullStr | RUNX1 promotes proliferation of cervical cancer through TGFB2-MAPK pathway |
| title_full_unstemmed | RUNX1 promotes proliferation of cervical cancer through TGFB2-MAPK pathway |
| title_short | RUNX1 promotes proliferation of cervical cancer through TGFB2-MAPK pathway |
| title_sort | runx1 promotes proliferation of cervical cancer through tgfb2 mapk pathway |
| topic | Cervical cancer RUNX1 Proliferation MAPK pathway TGFB2 Immune microenvironment |
| url | https://doi.org/10.1038/s41598-024-84254-x |
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