Inhibition of the ATP synthase c subunit ameliorates HDM/LPS-induced inflammatory responses in asthmatic bronchial epithelial cells by blocking the mPTP-mtDNA-cGAS-STING axis

Inhibition of the ATP synthase c subunit ameliorates HDM/LPS-induced inflammatory responses in asthmatic bronchial epithelial cells by blocking the mPTP-mtDNA-cGAS-STING axis

Abstract The ATP synthase c subunit (c subunit) constitutes the mitochondrial permeability transition pore (mPTP). The extended opening of the mPTP is crucial in the development of various human illnesses. Nevertheless, it remains unclear whether the c subunit regulates the prolonged opening of the...

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Main Authors: Decai Wang, Chao Liu, Chen Bao, Jiannan Hu, Ziling Li, Xinyue Ma, Yunfei Zhu, Shuyun Xu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Respiratory Research
Subjects:
Asthma
Airway epithelial cells
Inflammatory responses
Mitochondria
ATP synthase c subunit
Mitochondrial permeability transition pore
Online Access:https://doi.org/10.1186/s12931-025-03299-2
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https://doi.org/10.1186/s12931-025-03299-2

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