Characterising how a single bout of exercise in people with myeloma affects clonal plasma cell and immune effector cell frequency in blood, and daratumumab efficacy in vitro

Characterising how a single bout of exercise in people with myeloma affects clonal plasma cell and immune effector cell frequency in blood, and daratumumab efficacy in vitro

Multiple myeloma is a haematological cancer characterised by the accumulation of clonal plasma cells in the bone marrow and is commonly treated with daratumumab, an anti-CD38 monoclonal antibody immunotherapy. Daratumumab often fails to induce stringent complete responses, due in part to resistance...

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Bibliographic Details
Main Authors: Harrison D. Collier-Bain, Annabelle Emery, Frankie F. Brown, Adam J. Causer, Rebecca Oliver, Rachel Eddy, Shoji Leach, John Graby, Daniel Augustine, Sally Moore, Josephine Crowe, James Murray, James E. Turner, John P. Campbell
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Myeloma1
Daratumumab2
Exercise3
ADCC4
NK-cells5
monocytes5
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354624001431
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