IL6/CCL2 from M2-polarized microglia promotes breast cancer brain metastasis and the reversal effect of β-elemene

IL6/CCL2 from M2-polarized microglia promotes breast cancer brain metastasis and the reversal effect of β-elemene

IntroductionBrain metastasis (BM) is the most common and serious complication of breast cancer (BC). There is significant interest in investigating the crosstalk between BC cells and immune cells. β-elemene is the main pharmacodynamic component of Curcumae Rhizoma, a traditional Chinese medicine tha...

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Bibliographic Details
Main Authors:	Qian Feng, Cai-Zhi Li, Yi-Hua Zou, Xue-Yu Wang, Xia Yang, Rong Zhang, Zhong-Qiu Liu, Rong-Rong Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Pharmacology
Subjects:	breast cancer brain metastasis M2 microglia IL6 and CCL2 cytokines IL6-STAT3 signaling pathway β-elemene
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1547333/full
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