Development of a small compound that regulates the function of a maltodextrin-binding protein of Streptococcus pyogenes by multifaceted screenings

Development of a small compound that regulates the function of a maltodextrin-binding protein of Streptococcus pyogenes by multifaceted screenings

Abstract Group A Streptococcus (GAS) are gram-positive bacteria that cause various symptoms. The treatment of GAS infections currently relies on antibiotics, but new treatment options are needed due to the spread of antibiotic resistance. To develop novel treatment methods that circumvent the genera...

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Bibliographic Details
Main Authors: Tsukushi Yamawaki, Makoto Nakakido, Satoru Nagatoishi, Jose M. M. Caaveiro, Daisuke Kuroda, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Streptococcus pyogenes
Maltose/maltodextrin-binding protein
Small compound
Target based screening
Antimicrobial resistance
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Online Access:https://doi.org/10.1038/s41598-025-02175-9
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https://doi.org/10.1038/s41598-025-02175-9

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