Whole genome sequencing reveals virulence–mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria

Whole genome sequencing reveals virulence–mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria

BackgroundMultidrug-resistant Escherichia coli poses a critical public health threat in Nigeria, where limited genomic surveillance hinders the understanding of virulence-resistance interplay.MethodsThis cross-sectional study employed whole-genome sequencing to characterize 107 MDR-E isolates from a...

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Main Authors: Nubwa Medugu, Mabel Kamweli Aworh, Kenneth Iregbu, Philip Nwajiobi-Princewill, Dawn M. Hull, Lyndy Harden, Pallavi Singh, Stephen Obaro, Abiodun Egwuenu, Faith Adeboye, Ruth Egah, Leonard Uzairue, Yahaya Mohammed, Nwafia Ifeyinwa, Siddhartha Thakur
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Microbiology
Subjects:
multidrug-resistant Escherichia coli
virulence factors
phylogenetic diversity
whole-genome sequencing (WGS)
mobile genetic elements (MGEs)
IncFII plasmids
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1579175/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1579175/full

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