Dissecting the Distinct Tumor Microenvironments of HRD and HRP Ovarian Cancer: Implications for Targeted Therapies to Overcome PARPi Resistance in HRD Tumors and Refractoriness in HRP Tumors

Dissecting the Distinct Tumor Microenvironments of HRD and HRP Ovarian Cancer: Implications for Targeted Therapies to Overcome PARPi Resistance in HRD Tumors and Refractoriness in HRP Tumors

Abstract High‐grade serous tubo‐ovarian cancer (HGSTOC) is an aggressive gynecological malignancy including homologous recombination deficient (HRD) and homologous recombination proficient (HRP) groups. Despite the therapeutic potential of poly (ADP‐ribose) polymerase inhibitors (PARPis) and anti‐PD...

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Bibliographic Details
Main Authors: Junjun Qiu, Tingting Ren, Qinqin Liu, Qian Jiang, Tong Wu, Leong Chi Cheng, Wenqing Yan, Xinyu Qu, Xiao Han, Keqin Hua
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Advanced Science
Subjects:
high grade tubo‐ovarian cancer
HRD
HRP
precise treatment strategies
single‐cell RNA sequencing
single‐cell T cell receptor sequencing
Online Access:https://doi.org/10.1002/advs.202309755
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https://doi.org/10.1002/advs.202309755

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