Iron and siRNA co-encapsulated ferritin nanocages induce ferroptosis synergistically for cancer therapy

Iron and siRNA co-encapsulated ferritin nanocages induce ferroptosis synergistically for cancer therapy

Ferroptosis has received great attention as an iron-dependent programmed cell death for efficient cancer therapy. However, with the accumulation of iron in tumor cells, the antioxidant system is activated by reducing glutathione (GSH) with glutathione peroxidase 4 (GPX4), which critically limits the...

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Bibliographic Details
Main Authors: Danni Liu, Yaoqi Wang, Qi Sun, Dong Mei, Xiaoling Wang, Yan Su, Jie Zhang, Ran Huo, Yang Tian, Siyu Liu, Shuang Zhang, Chunying Cui
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ferroptosis
Ferritin
Iron homeostasis
siRNA
Gene silencing
Glutathione peroxidase 4
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524004064
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