Intraperitoneal administration of NMDA-Subunit NR1-receptor antibodies does not improve long-term outcome in a murine MCAo-stroke model

Intraperitoneal administration of NMDA-Subunit NR1-receptor antibodies does not improve long-term outcome in a murine MCAo-stroke model

Ischemic stroke is a major cause of disability worldwide, and current treatment is largely limited to thrombolytics. Therefore, additional therapeutic strategies are warranted. Previous evidence suggests that NMDA receptor antibodies targeting specific subunits may reduce excitotoxicity and lesion s...

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Bibliographic Details
Main Authors: Carolin Albrecht, Christoph Harms, Jakob Kreye, Matthias Endres, Susanne Mueller, Philipp Boehm-Sturm, Stefan Paul Koch, Dorette Freyer, Harald Prüss, Samuel Knauss
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Neuroscience
Subjects:
antibodies
excitotoxicity
MCAo
NMDA-receptor
stroke
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1614924/full
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https://www.frontiersin.org/articles/10.3389/fnins.2025.1614924/full

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