Identification of Co-29, a 5-cyano-2-thiacetyl aromatic pyrimidinone, as a potential inhibitor targeting the RdRp of norovirus

Identification of Co-29, a 5-cyano-2-thiacetyl aromatic pyrimidinone, as a potential inhibitor targeting the RdRp of norovirus

Abstract Background Human norovirus (HNV) is the predominant pathogen causing outbreaks of acute gastroenteritis globally. Despite significant efforts to combat norovirus infections, there is currently no FDA approved vaccine or antiviral drug available. Consequently, the development of effective an...

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Bibliographic Details
Main Authors: Xianglan Liu, Jiaming Hu, Jiarui Wu, Yiru Tian, Jinbo Wang, Chunyan Wu, Qingfeng Chen, Leonard Krall, Yanping He, Qun Lu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Virology Journal
Subjects:
Norovirus
RdRp
Anti-norovirus agent
Co-29
Online Access:https://doi.org/10.1186/s12985-025-02687-w
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https://doi.org/10.1186/s12985-025-02687-w

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