The Formyl Peptid Receptor Ligand Ac2-26 Improves the Integrity of the Blood−Brain Barrier in the Course of Pneumococcal Meningitis

The Formyl Peptid Receptor Ligand Ac2-26 Improves the Integrity of the Blood−Brain Barrier in the Course of Pneumococcal Meningitis

Background: The brain is protected from invading pathogens by the blood−brain barrier (BBB) and the innate immune system. Pattern recognition receptors play a crucial role in detecting bacteria and initiating the innate immune response. Among these are G-protein-coupled formyl peptide receptors (FPR...

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Bibliographic Details
Main Authors: Johannes Deutloff, Irina Pöhner, Johann Rößler, Markus Kipp, Simone C. Tauber, Lars-Ove Brandenburg
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
formyl peptide receptor
bacterial meningitis
blood-brain barrier
innate immunity
<i>Streptococcus pneumoniae</i>
annexin A1
Online Access:https://www.mdpi.com/2073-4409/13/24/2104
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