Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish

Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish

Abstract Cytosine base editing is a powerful tool for making precise single nucleotide changes in cells and model organisms like zebrafish, which are valuable for studying human diseases. However, current base editors struggle to edit cytosines in certain DNA contexts, particularly those with GC and...

Full description

Saved in:
Bibliographic Details
Main Authors: Yu Zhang, Yang Liu, Wei Qin, Shaohui Zheng, Jiawang Xiao, Xinxin Xia, Xuanyao Yuan, Jingjing Zeng, Yu Shi, Yan Zhang, Hui Ma, Gaurav K. Varshney, Ji-Feng Fei, Yanmei Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53735-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-024-53735-y

Similar Items