NSC632839 suppresses esophageal squamous cell carcinoma cell proliferation in vitro by triggering spindle assembly checkpoint-mediated mitotic arrest and CREB-Noxa-dependent apoptosis

NSC632839 suppresses esophageal squamous cell carcinoma cell proliferation in vitro by triggering spindle assembly checkpoint-mediated mitotic arrest and CREB-Noxa-dependent apoptosis

Abstract Objective Esophageal cancer is one of the most common digestive cancers in the world. Because of the limitation and resistence of the traditional chemotherapy drugs, it is important to explore new therapeutic targets and strategies for this refractory cancer. Recently, targeting deubiquitin...

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Main Authors: Shan Zhao, Guihong Dong, Yixuan Guo, Yaxin Sun, Miaomiao Li, Beibei Sha, Wenjing Huang, Yuan Zhang, Yue Du, Jie Yan, Yangcheng Ma, Ruiyi Yang, Jianxiang Shi, Pei Li, Tao Hu, Ping Chen
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cancer Cell International
Subjects:
Esophageal squamous cell carcinoma
NSC632839
Mitotic arrest
Apoptosis
Online Access:https://doi.org/10.1186/s12935-025-03831-w
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https://doi.org/10.1186/s12935-025-03831-w

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