The African swine fever virus p22 inhibits the JAK-STAT signaling pathway by promoting the TAX1BP1-mediated degradation of the type I interferon receptor.

The African swine fever virus p22 inhibits the JAK-STAT signaling pathway by promoting the TAX1BP1-mediated degradation of the type I interferon receptor.

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African swine fever virus (ASFV) is the causative agent of African swine fever (ASF), a devastating disease epidemic in Asia and Europe. Large knowledge gaps regarding the biological characteristics of viral structural proteins have severely hindered the development of vaccines against ASF. The p22...

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Main Authors: Haojie Ren, Yanjin Wang, Lian-Feng Li, Lan-Fang Shi, Yu-He Ma, Jun-Hao Fan, Xiao-Ya Pan, Han-Cheng Shao, Yuhang Zhang, Shichong Han, Bo Wan, Hua-Ji Qiu, Gai-Ping Zhang, Su Li, Wen-Rui He
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013319
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https://doi.org/10.1371/journal.ppat.1013319

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