Impact of rpoB gene mutations and Rifampicin-resistance levels on treatment outcomes in Rifampicin-resistant tuberculosis

Impact of rpoB gene mutations and Rifampicin-resistance levels on treatment outcomes in Rifampicin-resistant tuberculosis

Abstract Background Although many studies have examined the connection between mutations in the rpoB gene and drug resistance, the impact of common mutations on treatment outcomes for RR-TB is not yet fully understood. Objectives This study explores the relationship between rpoB gene mutations and d...

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Main Authors: Maria Jose Vadakunnel, Vijayalakshmi Jawaharlal Nehru, Usharani Brammacharry, Venkateswari Ramachandra, Suganthi Palavesam, Anbazhagi Muthukumar, Balasundaram Revathi Mani, Sriramkumar S. R, Gunavathy Pradhabane, Azger Dusthackeer VN, Sangeetha Subramani, Muthuraj Muthaiah, Govindarajan Soundappan
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Infectious Diseases
Subjects:
Mycobacterium tuberculosis
Disputed rpoB mutations
Low-level resistance
High-level resistance
Treatment outcomes
Minimal inhibitory concentration
Online Access:https://doi.org/10.1186/s12879-025-10655-6
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https://doi.org/10.1186/s12879-025-10655-6

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