Features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus

Features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus

Background: Metabolic and structural changes in cardiomyocytes in diabetes mellitus lead to aggravation of contractile myocardial dysfunction in coronary heart disease (CHD). The contractility dysfunction of cardiomyocytes is determined by a change in the levels of sarcoplasmic reticulum (SR) Ca2+-A...

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Main Authors: Sergey A. Afanasiev, Dina S. Kondratieva, Margarita V. Egorova, Shamil D. Akhmedov, Olesya V. Budnikova, Sergey V. Popov
Format: Article
Language:English
Published: Endocrinology Research Centre 2019-03-01
Series:Сахарный диабет
Subjects:
coronary heart disease
type 2 diabetes mellitus
contractility of isolated trabeculae
ca2+-atpase, succinate dehydrogenase
lactate dehydrogenase
oxidative phosphorylation
Online Access:https://www.dia-endojournals.ru/jour/article/view/9735
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