Epigenetic signatures in surrogate tissues are able to assess cancer risk and indicate the efficacy of preventive measures

Epigenetic signatures in surrogate tissues are able to assess cancer risk and indicate the efficacy of preventive measures

Abstract Background In order to advance personalized primary cancer prevention, surrogate endpoint biomarkers in distant, easy to access tissues (i.e., field defect indicators) reflecting field cancerization in the organ at risk are essential. Methods Here we utilized medroxyprogesterone acetate and...

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Main Authors: James E. Barrett, Chiara Maria Herzog, Sepideh Aminzadeh-Gohari, Elisa Redl, Isma Ishaq Parveen, Julia Rothärmel, Julia Tevini, Daniela D. Weber, Luca Catalano, Victoria E. Stefan, Thomas K. Felder, Peter Obrist, Twana Alkasalias, Kristina Gemzell-Danielsson, Roland Lang, Barbara Kofler, Martin Widschwendter
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00779-w
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https://doi.org/10.1038/s43856-025-00779-w

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