High gestational leucine level dampens WDPCP/MAPK signaling to impair the EMT and migration of cardiac microvascular endothelial cells in congenital heart defects

High gestational leucine level dampens WDPCP/MAPK signaling to impair the EMT and migration of cardiac microvascular endothelial cells in congenital heart defects

Abstract Congenital heart defects (CHDs) represent one of the most prevalent categories of neonatal defects, and maternal dietary patterns have been linked to the risk of these conditions. Branched‐chain amino acids (BCAAs), particularly leucine, are essential for various metabolic and physiological...

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Bibliographic Details
Main Authors: Wei Hong, Guozhou You, Zhongming Luo, Mingxiang Zhang, Jian Chen
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Pulmonary Circulation
Subjects:
congenital heart defects (CHDs)
EMCN
leucine
MAPK/ERK
WDPCP
Online Access:https://doi.org/10.1002/pul2.70013
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https://doi.org/10.1002/pul2.70013

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