Advancing Obsessive–Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies
Obsessive–compulsive disorder (OCD) is a prevalent, chronic, and severe neuropsychiatric disorder that leads to illness-related disability. Despite the availability of several treatments, many OCD patients respond inadequately, because the underlying neural mechanisms remain unclear, necessitating t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/15/1/43 |
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| author | Xinyuejia Huang Linglong Xiao Mengqi Wang Yang Wu Hao Deng Wei Wang |
| author_facet | Xinyuejia Huang Linglong Xiao Mengqi Wang Yang Wu Hao Deng Wei Wang |
| author_sort | Xinyuejia Huang |
| collection | DOAJ |
| description | Obsessive–compulsive disorder (OCD) is a prevalent, chronic, and severe neuropsychiatric disorder that leads to illness-related disability. Despite the availability of several treatments, many OCD patients respond inadequately, because the underlying neural mechanisms remain unclear, necessitating the establishment of many animal models, particularly mouse models, to elucidate disease mechanisms and therapeutic strategies better. Although the development of animal models is ongoing, there remain many comprehensive summaries and updates in recent research, hampering efforts to develop novel treatments and enhance existing interventions. This review summarizes the phenotypes of several commonly used models and mechanistic insights from transgenic models of OCD, such as knockout mouse models. In addition, we present the advantages and limitations of these models and discuss their future in helping further understand the pathophysiology and advanced treatment. Here, we highlight current frontline treatment approaches for OCD, including neuromodulation and surgical interventions, and propose potential future directions. By studying gene mutations and observing phenotypes from available OCD animal models, researchers have classified the molecular signatures of each model reminiscent of changes in brain areas and neural pathways, with the hope of guiding the future selection of the most appropriate models for specific research in the OCD field. |
| format | Article |
| id | doaj-art-6996fbc5d44c478f90658eb39adfad27 |
| institution | Kabale University |
| issn | 2076-3425 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj-art-6996fbc5d44c478f90658eb39adfad272025-01-24T13:25:47ZengMDPI AGBrain Sciences2076-34252025-01-011514310.3390/brainsci15010043Advancing Obsessive–Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative TherapiesXinyuejia Huang0Linglong Xiao1Mengqi Wang2Yang Wu3Hao Deng4Wei Wang5Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaObsessive–compulsive disorder (OCD) is a prevalent, chronic, and severe neuropsychiatric disorder that leads to illness-related disability. Despite the availability of several treatments, many OCD patients respond inadequately, because the underlying neural mechanisms remain unclear, necessitating the establishment of many animal models, particularly mouse models, to elucidate disease mechanisms and therapeutic strategies better. Although the development of animal models is ongoing, there remain many comprehensive summaries and updates in recent research, hampering efforts to develop novel treatments and enhance existing interventions. This review summarizes the phenotypes of several commonly used models and mechanistic insights from transgenic models of OCD, such as knockout mouse models. In addition, we present the advantages and limitations of these models and discuss their future in helping further understand the pathophysiology and advanced treatment. Here, we highlight current frontline treatment approaches for OCD, including neuromodulation and surgical interventions, and propose potential future directions. By studying gene mutations and observing phenotypes from available OCD animal models, researchers have classified the molecular signatures of each model reminiscent of changes in brain areas and neural pathways, with the hope of guiding the future selection of the most appropriate models for specific research in the OCD field.https://www.mdpi.com/2076-3425/15/1/43animal modeltreatmentobsessive–compulsive disorder (OCD)transgenicknockout (KO) |
| spellingShingle | Xinyuejia Huang Linglong Xiao Mengqi Wang Yang Wu Hao Deng Wei Wang Advancing Obsessive–Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies Brain Sciences animal model treatment obsessive–compulsive disorder (OCD) transgenic knockout (KO) |
| title | Advancing Obsessive–Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies |
| title_full | Advancing Obsessive–Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies |
| title_fullStr | Advancing Obsessive–Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies |
| title_full_unstemmed | Advancing Obsessive–Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies |
| title_short | Advancing Obsessive–Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies |
| title_sort | advancing obsessive compulsive disorder research insights from transgenic animal models and innovative therapies |
| topic | animal model treatment obsessive–compulsive disorder (OCD) transgenic knockout (KO) |
| url | https://www.mdpi.com/2076-3425/15/1/43 |
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