Heterotypic spheroids as a strategy for 3D culture of cryopreserved primary human hepatocytes in stirred-tank systems

Heterotypic spheroids as a strategy for 3D culture of cryopreserved primary human hepatocytes in stirred-tank systems

Primary human hepatocytes (PHHs) are the preferred cell source to address liver function. Despite originating from the native tissue, one of the bottlenecks when using primary material is the donor-to-donor variability. Cryopreserved PHHs offer a high number of cells from the same donor and standard...

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Bibliographic Details
Main Authors: Francisca Arez, Lena Preiss, Isabella Ramella Gal, Sofia P. Rebelo, Lassina Badolo, Catarina Brito, Thomas Spangenberg, Paula M. Alves
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:SLAS Discovery
Subjects:
Primary human hepatocytes
Spheroids
Stirred-tank culture systems
Co-culture strategy
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555225000036
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http://www.sciencedirect.com/science/article/pii/S2472555225000036

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