Nanocarrier-mediated siRNA delivery: a new approach for the treatment of traumatic brain injury–related Alzheimer’s disease

Nanocarrier-mediated siRNA delivery: a new approach for the treatment of traumatic brain injury–related Alzheimer’s disease

Traumatic brain injury and Alzheimer’s disease share pathological similarities, including neuronal loss, amyloid-β deposition, tau hyperphosphorylation, blood–brain barrier dysfunction, neuroinflammation, and cognitive deficits. Furthermore, traumatic brain injury can exacerbate Alzheimer’s disease-...

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Bibliographic Details
Main Authors: Jie Jin, Huajing Zhang, Qianying Lu, Linqiang Tian, Sanqiao Yao, Feng Lai, Yangfan Liang, Chuanchuan Liu, Yujia Lu, Sijia Tian, Yanmei Zhao, Wenjie Ren
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-09-01
Series:Neural Regeneration Research
Subjects:
blood–brain barrier
cognitive dysfunction
exosomes
gene silencing
immunotherapy
inorganic nanomaterials
liposome nanoparticles
neuroinflammation
polymer nanoparticles
stem cells
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-00303
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https://journals.lww.com/10.4103/NRR.NRR-D-24-00303

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