Mesenchymal stem cells overexpressing neuropeptide S promote the recovery of rats with spinal cord injury by activating the PI3K/AKT/GSK3β signaling pathway

Mesenchymal stem cells overexpressing neuropeptide S promote the recovery of rats with spinal cord injury by activating the PI3K/AKT/GSK3β signaling pathway

Abstract Background Transplantation of nasal mucosa-derived mesenchymal stem cells (EMSCs) overexpressing neuropeptide S (NPS) is a promising approach for treating spinal cord injury (SCI). Despite the potential of stem cell therapy, challenges remain regarding cell survival and differentiation cont...

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Bibliographic Details
Main Authors: Wenhui Yang, Yilu Li, Yushi Tang, Zhenxing Tao, Mengyuan Yu, Cuiping Sun, Yang Ye, Bai Xu, Xudong Zhao, Yazhuo Zhang, Xiaojie Lu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Stem Cell Research & Therapy
Subjects:
Neuropeptide S
Nasal mucosa mesenchymal stem cells
Transected spinal cord injury
PI3K/Akt/GSK3β pathway
Neural stem cells
Online Access:https://doi.org/10.1186/s13287-025-04250-4
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https://doi.org/10.1186/s13287-025-04250-4

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