Broad‐Spectrum Engineered Multivalent Nanobodies Against SARS‐CoV‐1/2

Broad‐Spectrum Engineered Multivalent Nanobodies Against SARS‐CoV‐1/2

Abstract SARS‐CoV‐2 Omicron sublineages escape most preclinical/clinical neutralizing antibodies in development, suggesting that previously employed antibody screening strategies are not well suited to counteract the rapid mutation of SARS‐CoV‐2. Therefore, there is an urgent need to screen better b...

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Bibliographic Details
Main Authors: Zhihong Wang, Zhuangzhuang Shi, Xiaochen Liao, Guiqi Quan, Hui Dong, Pinnan Zhao, Yangyihua Zhou, Ning Shi, Jie Wang, Yahui Wu, Chunxia Qiao, Xin ying Li, Ran Zhang, Zekun Wang, Tiecheng Wang, Xiang Gao, Jiannan Feng, Longlong Luo
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
antibody engineering
de novo design
multivalent nanobodies
nanobody
SARS‐CoV‐1
SARS‐CoV‐2
Online Access:https://doi.org/10.1002/advs.202402975
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https://doi.org/10.1002/advs.202402975

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