Three-dimensional cell sheet model improves in vitro prediction accuracy of osteogenic potential for biodegradable magnesium-based metals

Three-dimensional cell sheet model improves in vitro prediction accuracy of osteogenic potential for biodegradable magnesium-based metals

Biodegradable metals have been increasingly utilized clinically due to their biosafety and pro-osteogenic properties. However, conventional monolayer cell-based preclinical safety evaluation methods based on ISO10993-5 consistently indicate significant cytotoxicity that contradicts in vivo outcomes....

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Bibliographic Details
Main Authors: Liangwei Chen, Guanxi Wu, Siyu Liu, Ziyu Yan, Honglei Yue, Jianhua Zhu, Na Ge, Yifei Wang, Qingxiang Li, Guanqi Liu, Tingting Zhang, Haowen Zheng, Shaozhe Xin, Guangyunhao Sun, Chuanbin Guo, Jianmin Han
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-12-01
Series:Bioactive Materials
Subjects:
Cell sheet model
Biodegradable metals
N-Cadherin
In vitro evaluation model
Osteogenic ability
Magnesium-based metals
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25003652
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