Nonviral targeted mRNA delivery: principles, progresses, and challenges

Nonviral targeted mRNA delivery: principles, progresses, and challenges

Abstract Messenger RNA (mRNA) therapeutics have garnered considerable attention due to their remarkable efficacy in the treatment of various diseases. The COVID‐19 mRNA vaccine and RSV mRNA vaccine have been approved on the market. Due to the inherent nuclease‐instability and negative charge of mRNA...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xi He, Guohong Li, Letao Huang, Haixing Shi, Sha Zhong, Siyu Zhao, Xiangyu Jiao, Jinxiu Xin, Xiaoling Yin, Shengbin Liu, Zhongshan He, Mengran Guo, Chunli Yang, Zhaohui Jin, Jun Guo, Xiangrong Song
Format:	Article
Language:	English
Published:	Wiley 2025-01-01
Series:	MedComm
Subjects:	delivery obstacles mRNA therapeutics nonviral delivery targeted delivery systems
Online Access:	https://doi.org/10.1002/mco2.70035
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Current issues with antibody-conjugated lipid nanoparticles
by: Aayush
Published: (2025-02-01)

CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA
by: Zachary F. Mandell, et al.
Published: (2025-03-01)

Local delivery of TGF-β1-mRNA decreases fibrosis in osteochondral defects
by: Gianluca Fontana, et al.
Published: (2025-03-01)

Precise intracellular uptake and endosomal release of diverse functional mRNA payloads via glutathione-responsive nanogels
by: Rupali Dabas, et al.
Published: (2025-02-01)

In vivo production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection
by: Yuta Suzuki, et al.
Published: (2025-03-01)

Vector‐Free Deep Tissue Targeting of DNA/RNA Therapeutics via Single Capacitive Discharge Conductivity‐Clamped Gene Electrotransfer
by: Jeremy L. Pinyon, et al.
Published: (2025-01-01)

Flow rate modulates focused ultrasound-mediated vascular delivery of microRNA
by: Stephanie He, et al.
Published: (2025-03-01)

Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines
by: Aziz A. Chentoufi, et al.
Published: (2024-12-01)

Approaches and applications in transdermal and transpulmonary gene drug delivery
by: Anni Zhang, et al.
Published: (2025-01-01)

Bioadhesive Chitosan Films Loading Curcumin for Safe and Effective Skin Cancer Topical Treatment
by: Seila Tolentino, et al.
Published: (2024-12-01)

Calcium Phosphate Nanoparticles Functionalized with a Cardio-Specific Peptide
by: Federica Mancini, et al.
Published: (2025-01-01)

The modification of conventional liposomes for targeted antimicrobial delivery to treat infectious diseases
by: Nnamdi Ikemefuna Okafor, et al.
Published: (2025-01-01)

Testing the Rule of the Earliest Due Date (EDD) in Achieving the Priority of Delivery: A Case Study in the Directorate of Printing Press for the Iraqi Media Network
by: Amer Abdul Latif Kazem, et al.
Published: (2022-09-01)

Communication and Delivery of Project Activities: A Case Study of Selected Organisations in Kabale Municipality
by: AINE, ONAN
Published: (2022)

Prospective cohort study comparing outcomes between vacuum extraction and second-stage cesarean delivery at a Ugandan tertiary referral hospital
by: Barbara, Nolens, et al.
Published: (2019)

Effect of the size of nucleic acid delivery systems on their fate in cancer treatment
by: Mengyun Ye, et al.
Published: (2024-02-01)

The future of capsule endoscopy in clinical practice: from diagnostic to therapeutic experimental prototype capsules
by: Michael Vasilakakis, et al.
Published: (2019-09-01)

Influence of mode of delivery on infant gut microbiota composition: a pilot study
by: Li Yu, et al.
Published: (2024-12-01)

Mediolateral episiotomy and obstetric anal sphincter injuries in nullipara: a propensity score matching study
by: Or Bercovich, et al.
Published: (2025-01-01)

Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease
by: Wang H, et al.
Published: (2025-02-01)

Localized Drug Delivery in Different Gastrointestinal Cancers: Navigating Challenges and Advancing Nanotechnological Solutions
by: Hasan AM, et al.
Published: (2025-01-01)

Building of Future Intelligent Content Pipeline Based on Unified CDN
by: Qin Yin, et al.
Published: (2015-04-01)

Modes of delivery and indications in women with COVID-19: a regional observational study in Japan
by: Shoichi Magawa, et al.
Published: (2024-12-01)

Hematocervix as an Uncommon Complication of Cesarean Delivery: A Case Report
by: Ozlem ece Basaran, et al.
Published: (2020-12-01)

Information Communication Technology and Service Delivery in Nyagatare District Local Goverment, Rwanda.
by: Wellars, Kanamugire
Published: (2020)

Citizen Participation and Service Delivery: A case of Communities in Rukungiri Municipality.
by: Jonacent, Tumusiime
Published: (2020)

Associations between different types of delivery, empathy, aggression, impulsivity and school bullying in children attending public and private schools in Pereira (Colombia)
by: Julio C. Sánchez, et al.
Published: (2025-02-01)

Cardiovascular Complications During Delivery Hospitalization in Patients With Psoriasis
by: Ankit Agrawal, MD, et al.
Published: (2025-02-01)

Revolutionizing healthcare delivery with blockchain technology
by: S Saravanan
Published: (2024-09-01)

Development, opportunities, and challenges of siRNA nucleic acid drugs
by: Bowen Xiao, et al.
Published: (2025-03-01)

Mitochondrial-targeted therapies in traumatic brain injury: From bench to bedside
by: Sidra Tabassum, et al.
Published: (2025-01-01)

Current advancements in microneedle technology for therapeutic and biomedical applications
by: Olivia Sen, et al.
Published: (2025-01-01)

Key criteria for choosing restaurants and food delivery scenarios in Moscow
by: D. A. Khokhlov, et al.
Published: (2024-03-01)

Scalable Manufacturing Method for Model Protein-Loaded PLGA Nanoparticles: Biocompatibility, Trafficking and Release Properties
by: Selin Akpinar Adscheid, et al.
Published: (2025-01-01)

The Future of Last-Mile Delivery: Lifecycle Environmental and Economic Impacts of Drone-Truck Parallel Systems
by: Danwen Bao, et al.
Published: (2025-01-01)

Cesarean delivery on child health and development in Japanese nationwide birth cohort
by: Naomi Matsumoto, et al.
Published: (2025-01-01)

Polymer nanocomposites in diabetes management: advances in biosensors and drug delivery systems
by: Aniruddha Sen
Published: (2025-02-01)

Recent Advances in Peptide-Loaded PLGA Nanocarriers for Drug Delivery and Regenerative Medicine
by: Hossein Omidian, et al.
Published: (2025-01-01)

Harnessing nanotechnology for cancer treatment
by: Jiajun Zhu, et al.
Published: (2025-01-01)

Son Kilometre (Adım) Teslimatta Blokzincir Teknolojisinin Kullanımı
by: Makber Tekin, et al.
Published: (2023-01-01)