Rapid and high-yield recovery of plasma-derived extracellular vesicles using modified chromatography with soluble protein depletion for biomarker discovery

Rapid and high-yield recovery of plasma-derived extracellular vesicles using modified chromatography with soluble protein depletion for biomarker discovery

Abstract Extracellular vesicles (EVs) are critical mediators of intercellular communication by transferring proteins, lipid and nucleic acids between cells. EVs in biofluids, particularly blood, have gathered significant interest as potential biomarkers for disease diagnosis. However, isolating EVs...

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Main Authors: Yang You, Zhengrong Zhang, Samuel Cortes, Son N. Nguyen, Prakruthi Vadakattu, Bridgette C. Melvin, Sean D. Jr Mann, Nibedita Basu Ray, Maria Bregendahl, Pam J. McLean, Maria Paz Gonzalez-Perez, Seiko Ikezu, Tsuneya Ikezu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell Communication and Signaling
Subjects:
Capto core 700 bead
Extracellular vesicle
Plasma
Data-independent-acquisition mass spectrometry
Biomarker
Neurodegenerative disorders
Online Access:https://doi.org/10.1186/s12964-025-02263-3
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https://doi.org/10.1186/s12964-025-02263-3

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