Reprogramming of iPSCs to NPCEC-like cells by biomimetic scaffolds for zonular fiber reconstruction

Reprogramming of iPSCs to NPCEC-like cells by biomimetic scaffolds for zonular fiber reconstruction

Ectopia lentis (EL), characterised by impaired zonular fibers originating from non-pigmented ciliary epithelial cells (NPCEC), presents formidable surgical complexities and potential risks of visual impairment. Cataract surgery is the only treatment method for EL, but it leads to the loss of accommo...

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Main Authors: Tianhui Chen, Zhongxing Chen, Juan Du, Min Zhang, Zexu Chen, Qingyi Gao, Aodong Chen, Qinghao Meng, Yang Sun, Yan liu, Linghao Song, Xinyue Wang, Pranav Prakash Edavi, Chen Xu, Hongmei Zhang, Jinhai Huang, Yongxiang Jiang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-03-01
Series:Bioactive Materials
Subjects:
Ectopia lentis
Zonular fiber reconstruction
Induced pluripotent stem cells
Biomimetic scaffolds
In situ regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24005231
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