Tamarix honey phenolics attenuate cisplatin-induced kidney toxicity by inhibition of inflammation mediated IL-6/STAT3/TNF-α and oxidative stress-dependent Nrf2/caspase-3 apoptotic signaling pathways

Tamarix honey phenolics attenuate cisplatin-induced kidney toxicity by inhibition of inflammation mediated IL-6/STAT3/TNF-α and oxidative stress-dependent Nrf2/caspase-3 apoptotic signaling pathways

IntroductionCisplatin (CIS) is a productive chemotherapeutic agent that is effective against a variety of cancer types. Its utilization is linked to acute kidney injury and other adverse consequences. Among its toxic effects are oxidative stress, apoptosis as well as inflammation. Saudi Tamarix hone...

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Main Authors: Hanan Aati, Sultan Y. Aati, Hebatallah S. Bahr, Asmaa Ramadan Abdel-Sattar, Marwa Ahmed Embaby, Ahmed M. Reda, Usama Ramadan Abdelmohsen, Gerhard Bringmann, Hossam M. Hassan, Mostafa A. Darwish
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
cisplatin
nephrotoxicity
caspase-3
Nrf2
oxidative stress
STAT3 cisplatin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1584832/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1584832/full

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