Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes

Contractility and cell motility depend on accurately controlled assembly of the actin cytoskeleton. Formins are a large group of actin assembly proteins that nucleate and elongate new actin filaments. Some formins may cap filaments while others sever or bundle filaments. The formin homology domain-c...

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Bibliographic Details
Main Authors: Dylan A Valencia, Angela N Koeberlein, Haruko Nakano, Akos Rudas, Aanand A Patel, Airi Harui, Cassandra Spencer, Atsushi Nakano, Margot E Quinlan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
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Online Access:https://elifesciences.org/articles/104048
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