Tumor-Targeted Cell-Penetrating Peptides Reveal That Monomethyl Auristatin E Temporally Modulates the Tumor Immune Microenvironment

Tumor-Targeted Cell-Penetrating Peptides Reveal That Monomethyl Auristatin E Temporally Modulates the Tumor Immune Microenvironment

Chemotherapies remain standard therapy for cancers but have limited efficacy and cause significant side effects, highlighting the need for targeted approaches. In the progression of cancer, tumors increase matrix metalloproteinase (MMP) activity. Leveraging and therapeutically redirecting tumor MMPs...

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Bibliographic Details
Main Authors: Mahsa Mortaja, Marcus M. Cheng, Alina Ali, Jacqueline Lesperance, Dina V. Hingorani, Mike M. Allevato, Kanika Dhawan, Maria F. Camargo, Rana R. McKay, Stephen R. Adams, J. Silvio Gutkind, Sunil J. Advani
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
peptide–drug conjugates
cell-penetrating peptides
anti-tubulins
matrix metalloproteinases
Online Access:https://www.mdpi.com/1420-3049/29/23/5618
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