Inhibition of TGF-β signaling enhances osteogenic potential of iPSC-derived MSCs

Abstract Mesenchymal stem cells (MSCs) represent the most commonly utilized type of stem cell in clinical applications. However, variability in quality and quantity between different tissue sources and donors presents a significant challenge to their use. Induced pluripotent stem cells (iPSCs) are a...

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Bibliographic Details
Main Authors: Felix Umrath, Sarah-Lena Frick, Valerie Wendt, Andreas Naros, Rüdiger Zimmerer, Dorothea Alexander
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-89370-w
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