Identifying genetically predisposed type 1 diabetes mellitus individuals in a Southern Brazilian population: The construction of a genetic risk score

Identifying genetically predisposed type 1 diabetes mellitus individuals in a Southern Brazilian population: The construction of a genetic risk score

Abstract Single nucleotide polymorphisms (SNPs) in the HLA DR/DQ region have the greatest impact on susceptibility to type 1 diabetes mellitus (T1DM). Non-HLA SNPs interact with the HLA, influencing the risk for T1DM. The aim of this study was to develop a genetic risk score (GRS) based on HLA DR/DQ...

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Main Authors: Felipe Mateus Pellenz, Mayara Souza de Oliveira, Guilherme Coutinho Kullmann Duarte, Natália Emerim Lemos, Cristine Dieter, Luís Henrique Canani, Taís Silveira Assmann, Daisy Crispim
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2025-04-01
Series:Genetics and Molecular Biology
Subjects:
Race adjusted-genetic risk score
HLA DR/DQ
single nucleotide polymorphisms
type 1 diabetes mellitus
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572025000200101&lng=en&tlng=en
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