An Argonaute from Thermus parvatiensis exhibits endonuclease activity mediated by 5′ chemically modified DNA guides

An Argonaute from Thermus parvatiensis exhibits endonuclease activity mediated by 5′ chemically modified DNA guides

Prokaryotic Argonaute (pAgo) nucleases with precise DNA cleavage activity show great potential for gene <sc>manipulation</sc>. Extensive biochemical studies have revealed that recognition of guides with different 5′ groups by Ago is important for biocatalysis. Here, we identified an Ago...

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Bibliographic Details
Main Authors: Sun Yingying, Guo Xiang, Lu Hui, Chen Liuqing, Huang Fei, Liu Qian, Feng Yan
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-05-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
Argonaute
<italic>Thermus parvatiensis</italic>
endonuclease
5′-modified guide
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022047
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https://www.sciengine.com/doi/10.3724/abbs.2022047

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