Mucoprotectants and gut barrier: mechanisms of action and clinical applications in IBS. Is there a possible role?

Mucoprotectants and gut barrier: mechanisms of action and clinical applications in IBS. Is there a possible role?

Impaired gut barrier function plays a pivotal role in the pathophysiology of irritable bowel syndrome (IBS), particularly in IBS with diarrhea. Mucoprotectants, such as xyloglucan, gelatin tannate and pea protein tannins, offer a novel therapeutic approach by restoring intestinal permeability and re...

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Bibliographic Details
Main Authors: Francesco Rettura, Christian Lambiase, Riccardo Tedeschi, Antonio Grosso, Lorenzo Cancelli, Angelo Ricchiuti, Andrea Bottari, Luca Giacomelli, Nicola de Bortoli, Massimo Bellini
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
irritable bowel syndrome
IBS-D
gut barrier function
mucoprotectants
xyloglucan
gelatin tannate
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1538791/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1538791/full

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